Get an Estradiol
Prescription Online

Get a new Estradiol prescription or refill your medication online.

Get a Prescription

Available in 50 states. No insurance needed.

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How to get an Estradiol prescription online?

Download the DrHouse app. Set up your free account in a minute.


Start a visit with an online doctor. Wait time is less than 15 minutes.


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How much does a visit to get an Estradiol prescription cost?

Physician Visit
One-time visit with a physician for diagnosis, treatment, Rx, labs, referrals, and doctor’s notes.
Copay or $129 without insurance.
24/7 virtual visits
See the first available physician, or schedule a visit with a physician you like.
Live customer support
Chat with our customer support whenever necessary. They are here for you 24/7.
Get a real doctor’s note
Get a doctor’s excuse and/or clearance for your school or work if needed.
100% treatment guarantee
You can request a refund after your visit if we are unable to provide care.
Having a visit does not guarantee a medication will be ordered or refilled. It is clinicians’ professional decision. It is prohibited by law to prescribe or refill controlled substances via virtual visits. Your provider may recommend follow-up care, including additional services that may not be included in visit price.

See why people turn to DrHouse...



Estradiol is a medicine that is a female hormone. The hormone is also referred to as E2 and has a chemical formula of C18H24O2. It is used to support women as their body’s natural estrogen production levels start to fall. The medicine can be taken in several ways including oral tablets, injections, and topical creams. Oral tablets are one of the most popular choices.

The naturally-occurring bioidentical hormone plays a key role in a woman’s biological development. It was discovered in 1933 but has since become a significant medication with over 12 million prescriptions in America annually.

Estradiol is available under several brand names or generic medicine. It is also made available with progestogens. As a female hormone, it is only available for females who have reached biological maturity. Most patients are in the 40+ demographic while it is now the estrogen medicine with the 3rd-highest level of prescriptions after birth control pills and ethinylestradiol.

What is Estradiol Prescribed For?

Estradiol is prescribed primarily for the treatment of symptoms linked to the menopause, including vaginal dryness and hot flashes. In addition to treating symptoms linked exclusively to the vagina, it is a useful treatment to prevent menopause-linked bone loss. As well as playing a key role in menopause hormonal therapy, estradiol is used in hormonal therapy for transgender women.

It may also be prescribed for treating low sex drives or as a form of hormonal birth control. Relieving the discomfort caused by hormonal imbalances during menopause. In many cases, the medicine will be used for several years (albeit in cycles) to cope with the bodily changes.

How Does Estradiol Work?

Estradiol is a naturally-occurring estrogen. Therefore, the main purpose of the medicine is to make up for the estrogen that is no longer produced by the body. Dosages are determined by personal estrogen levels and the severity of the menopause symptoms that may be experienced.

Whichever way you choose to administer the estradiol hormone, you will need to follow a schedule such as three weeks of daily injections followed by one week off. Some benefits may be experienced after a few days, but it can take weeks for estrogen levels gained from natural generation and the use of estradiol to reach their rightful outcome.

What Are The Side Effects of Estradiol?

Estradiol will alter your hormones in a big way. While it has a positive overall influence for the long haul, a long list of side effects can surface in the vaginal area as well as the entire body. Some of the most common side effects are;

  • Breast tenderness,
  • Melasma,
  • Cramps,
  • Anxiety,
  • Lightheadedness, 
  • Influenza,
  • Spotting,
  • Toothache,
  • Vaginal discharge,
  • Fluctuating weight.

You may also experience mild menopause symptoms until the estradiol has had a chance to restore hormonal balance during this difficult time. The symptoms will continue to become less noticeable until the medicine sees them fade completely.

Frequently Asked Questions About Estradiol

Is Estradiol the Same as Estrogen?

No, but it is easy to understand why they are used interchangeably. Estradiol, or E2, is a type of estrogen. While it is the most common form during the reproductive years, there are other estrogen forms. Estrone (E1) and Estriol (E3) are two additional examples of estrogen to highlight the difference.

How to Take Estradiol?

Estradiol can be taken in several forms. Creams can be applied to the localized area while tablets can be consumed with a glass of water. Dosages are built around your personal needs and the response to any treatment, doctors will provide clear information and advice before revisiting the strategy after a few weeks.

What to Avoid While Taking Estradiol?

If using an extended-release tablet, you must avoid chewing it as this can release all of the medicine at once.

You should also avoid eating grapefruit and smoking.

If you are using medications for any other condition, it is important to advise the doctor of this as the interactions could reduce the symptom relief attributes.

Can You Get Estradiol Over the Counter?

No, estradiol is a prescription medication and cannot be obtained over the counter.

Can You Get an Estradiol Prescription Online?

Yes, you can receive an online prescription for Estradiol from DrHouse if deemed appropriate or necessary by our providers based on your condition, individual needs, and medical history.


For more detailed information about estradiol, you can refer to the following sources:


The content on this page has been medically reviewed for accuracy and comprehensiveness by Amy Dougherty, FNP-BC, AGAC 

Content on the DrHouse website is written by our medical content team and reviewed by qualified MDs, PhDs, NPs, and PharmDs. We follow strict content creation guidelines to ensure accurate medical information. However, this content is for informational purposes only and not a substitute for professional medical advice, diagnosis, or treatment. For more information read our medical disclaimer.

Always consult with your physician or other qualified health providers about medical concerns. Never disregard professional medical advice or delay seeking it based on what you read on this website.

If you are experiencing high fever (>103F/39.4C), shortness of breath, difficulty breathing, chest pain, heart palpitations, abnormal bruising, abnormal bleeding, extreme fatigue, dizziness, new weakness or paralysis, difficulty with speech, confusion, extreme pain in any body part, or inability to remain hydrated or keep down fluids or feel you may have any other life-threatening condition, please go to the emergency department or call 911 immediately.

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Frequently asked questions

  • Yes, you can get a new prescription or refill an existing one online through DrHouse. You just need to start a consultation with one of our licensed providers and they will be able to assess your needs and provide you with a prescription if necessary.

    Please note that the final decision always rests with the doctor based on their professional judgment and your health needs.

  • There are certain medications that cannot be prescribed online by DrHouse physicians due to safety reasons. These include controlled substances, such as opioids and other narcotics, as well as drugs with a high potential for abuse or dependence. DrHouse physicians also don’t prescribe Gabapentin, medical marijuana, muscle relaxants, and HRT medications.

  • With DrHouse getting a new prescription or a refill for your current Rx is a straightforward and quick process. All you need to do is follow a few easy steps:

    • Download the DrHouse telehealth app on your mobile device.
    • Create an account by providing basic information and medical history.
    • Start an on-demand virtual video consultation with one of our licensed physicians.
    • Discuss your medical needs and concerns with one of our physicians.
    • A doctor will review your medical history, symptoms, and current medications (if any) to determine if an online prescription is appropriate for you.
    • If a physician approves, they will electronically send a new prescription or refill request to the pharmacy of your choice.
    • Pick up your medication from the pharmacy.

    DrHouse makes it easy for you to get an online prescription from the comfort of your own home. No more waiting in line at the doctor’s office or pharmacy, and no need to take time off work to see a doctor. Our telehealth platform allows you to access quality medical care from anywhere with an internet connection.

    For more information about how our telehealth platform works visit our “How DrHouse Works” page.

  • During your virtual consultation with a DrHouse physician, you will have the opportunity to discuss your medical needs and concerns.

    The consultation will consist of a video call where a physician will assess your medical history and ask you questions about your symptoms and any other relevant information. This is to ensure that a physician has all the necessary information to make an informed decision about your prescription.

    You can also ask any questions or clarify any doubts you may have about your condition or medication. Our physicians are happy to address any concerns you may have.

    Once a physician has assessed your needs, they will determine if and what type of prescription is appropriate for you. If a new prescription or refill is approved, a doctor will send it electronically to your chosen pharmacy.

  • With our on-demand telehealth service, you have the opportunity to see the first available doctor in as little as 10 to 15 minutes. However, the exact consult time will depend on the complexity of your case and the thoroughness required by the healthcare provider to make an informed decision.

  • Absolutely, it is safe to get an online prescription from DrHouse. We are committed to ensuring the highest standards of patient safety and privacy.

    All our providers are highly qualified US-based physicians and often affiliated with major hospitals. They are board-certified and from the top U.S. medical schools with an average of 20 years of experience.

    We strictly adhere to HIPAA regulations, ensuring your personal and medical information is kept secure and confidential. Also, we comply with all applicable state and federal laws related to telehealth and the prescribing of medications.

    Therefore, you can rest assured knowing that your safety and privacy are our top priorities when you use DrHouse’s services.

  • DrHouse strives to provide accessible and affordable telehealth services. DrHouse urgent care, primary care, and specialist visits are $129 or your copay. This includes everything from your initial consultation through to the prescription of your medication.

    The cost of a doctor’s visit may be covered fully by your insurance. A typical copay is around $25. We recommend checking with your insurance provider to understand the extent of your coverage for telehealth services.

    To learn more about how much DrHouse costs, visit our pricing page

  • Yes, DrHouse accepts most major insurances, including Blue Cross Blue Shield, Aetna, and Medicare. The extent of coverage may vary depending on your individual plan.

  • Our physicians are able to prescribe up to a 90-day prescription without labs for any previously prescribed medication if it’s medically appropriate and is not classified as a controlled substance.

    DrHouse physicians also don’t prescribe Gabapentin, medical marijuana, muscle relaxants, and HRT medications.

    DrHouse physicians use their medical judgment to determine whether to prescribe and the duration.

    In certain cases, the prescription may be limited to 30 days or less. There also may be a 12-month cap for some prescriptions without labs. For medications requiring annual monitoring (such as blood work or imaging), the maximum prescription limit is 90 days within a year without labs.

    DrHouse physicians can refer patients to labs for longer prescription periods or refills.