How to request a Xofluza prescription online

Patients can start a virtual visit through the DrHouse mobile app. The general process works like this:

• Download the DrHouse app from the Apple App Store or Google Play and create an account.
• Enter the reason for the visit and select insurance or self-pay.
• Choose a physician based on availability, specialty, ratings, and language.
• Book the next available appointment or schedule one for later.
• Complete the intake form with health history, current medications, allergies, and any relevant lab results.
• Join the secure video visit at the scheduled time.
• Speak with a licensed U.S. MD or DO physician about symptoms, history, and treatment goals.
• If the physician determines that Xofluza is medically appropriate, the prescription is sent electronically to a chosen pharmacy or, in supported locations, made available for same-day delivery.

DrHouse is available 24/7 in all 50 U.S. states.

What will your DrHouse doctor ask?

Have a few answers ready, because they decide whether Xofluza fits and which dose you need. Your doctor will ask when your symptoms started or when you were exposed, and what you weigh. They’ll also ask about health conditions such as asthma, diabetes, heart disease or a weakened immune system.

Tell them every medicine and supplement you take, especially antacids, laxatives, calcium, iron, magnesium or zinc. Mention it if you’re pregnant or breastfeeding, and if you’ve ever had an allergic reaction to a medicine.

Do you need a flu test first?

Not always. CDC tells clinicians not to wait for lab results before starting treatment when flu is suspected, and says early treatment can be based on clinical judgment, including without an office visit. Your DrHouse doctor will weigh your symptoms and how much flu is going around, and can refer you to a Labcorp location if testing would help.

Why the 48-hour window matters

Xofluza is approved for people who’ve had symptoms for 48 hours or less, and CDC says flu antivirals work best when started early, ideally within two days after symptoms begin. Flu rarely keeps office hours. DrHouse doctors are available 24/7, including nights, weekends and holidays, so a fever that starts at midnight doesn’t have to cost you a day.

Pharmacy pickup or same-day delivery

Prescriptions usually reach your pharmacy within 15 to 45 minutes after the visit, and you can choose almost any retail or mail-order pharmacy. Stock can change quickly in flu season, so it’s worth calling ahead. If your pharmacy is out, it can usually transfer the prescription to another location.

In select areas, you can choose same-day delivery through our partner pharmacies instead, sometimes in as little as an hour, with a photo ID check at the door.*

Insurance and your Xofluza visit

DrHouse accepts many major plans, including Medicare, Blue Cross Blue Shield, UnitedHealthcare, Aetna, Humana and Elevance Health (formerly Anthem) plans. With insurance, the typical copay for your video visit is $0 to $30, depending on your plan’s copay, deductible and coinsurance. Without insurance, the visit is $129, and HSA and FSA cards work where your plan allows.

When will your doctor suggest something else?

Xofluza isn’t right for everyone. Your doctor may recommend a different antiviral, such as oseltamivir (Tamiflu), or no antiviral at all. That can happen if you’re pregnant, if your symptoms started more than two days ago, or if the patient is under 5 or can’t swallow a tablet. If your symptoms need an exam, imaging or urgent attention, your doctor will tell you where to go.

Xofluza for kids at DrHouse

Xofluza is approved for children 5 and older, and for now it’s generally limited to kids who weigh at least 20 kg and can swallow a tablet. For any patient under 18, a parent or legal guardian must be present during the video visit. Add your child to your account so they have their own medical record, and start a separate visit for each child.

A doctor’s note for the flu

If the flu keeps you home from work or school, your DrHouse doctor can write a signed doctor’s note when medically appropriate. It’s usually emailed within about an hour and comes with your visit. Whether it’s accepted is up to your employer or school.

Who you’ll see

Every DrHouse visit is with a licensed U.S. physician, an MD or DO, and our doctors average 20 years of experience.

Privacy and security

DrHouse is HIPAA-compliant, and visits run over an encrypted connection. We also hold LegitScript Healthcare Merchant Certification, which verifies that telemedicine services that prescribe medication online meet healthcare and regulatory standards.

Not sure it’s the flu?

Considering Tamiflu instead? Request a Tamiflu prescription online. Not sure it’s the flu at all? See a doctor for cold and flu treatment.

Is Xofluza better than Tamiflu?

Neither is better for everyone. CDC describes the two as comparable for shortening flu symptoms, and in the trial that compared them in adults, both eased symptoms in a median of about 54 hours. The differences are practical: Xofluza is one dose for ages 5 and up, while Tamiflu is taken twice a day for five days, is approved from 2 weeks old, and is CDC’s preferred choice in pregnancy.

How fast does Xofluza work?

In clinical trials, Xofluza eased flu symptoms about a day sooner than a placebo. Otherwise healthy people ages 12 to 64 felt better in a median of 54 hours, compared with 80 hours on placebo, and people at higher risk of complications improved in 73 hours versus 102. You may still feel sick for a couple of days after the dose, so starting early matters most.

Is there a generic version of Xofluza?

Yes. On June 17, 2026, the FDA approved the first generic of Xofluza, baloxavir marboxil tablets from Norwich Pharmaceuticals, for the same uses as the brand. Your pharmacy may stock either version, so ask which one it has. The 48-hour treatment window applies to both, and your DrHouse doctor decides whether baloxavir is right for you.

Are you still contagious after taking Xofluza?

Assume you can still spread the flu. Xofluza isn’t FDA-approved to keep you from passing flu to others, even though CDC notes it quickly lowers the amount of virus in the upper airways. Keep doing what you would with any flu: stay home while you’re sick, cover coughs and sneezes, and keep your distance from people at higher risk, such as babies, older adults and anyone who’s pregnant.

What happens if you take Xofluza after 48 hours?

Xofluza is approved for people who’ve had symptoms for 48 hours or less, and CDC notes there’s no data on starting it later in people who aren’t hospitalized. If you’re past that window, it’s still worth talking to a doctor, especially if you’re at higher risk of complications or getting worse. They can tell you whether another treatment makes sense or whether you should be seen in person.

Can Xofluza prevent the flu?

Yes, after an exposure. For people 5 and older, one dose taken within 48 hours of contact with someone who has the flu is FDA-approved for prevention. In the household study behind that approval, 2% of people who took Xofluza got the flu, compared with 13% of those on a placebo. It doesn’t replace your yearly flu vaccine, which CDC calls the best way to prevent flu.

Is Xofluza available over the counter?

No. Xofluza and generic baloxavir need a prescription in the U.S., like every flu antiviral. You don’t need an office visit to get one, though. A DrHouse doctor can see you by video at any hour and prescribe Xofluza if it’s medically appropriate, and then you choose pickup at a pharmacy near you or same-day delivery in select areas.*

Can kids take Xofluza?

Xofluza is FDA-approved for children 5 and older. Because the liquid form isn’t currently available in the U.S., it’s generally limited to kids who weigh at least 20 kg (about 44 lb) and can swallow a tablet. For younger or smaller children, oseltamivir (Tamiflu) liquid is the usual alternative. On DrHouse, a parent or legal guardian must join the video visit for any patient under 18.

Can I take Xofluza while pregnant or breastfeeding?

CDC doesn’t recommend it. There aren’t adequate studies of baloxavir in pregnancy and no data on whether it passes into breast milk, so CDC names oral oseltamivir (Tamiflu) the preferred antiviral during pregnancy. Flu can be more serious when you’re pregnant, so if you have symptoms, see a doctor right away and mention that you’re pregnant or breastfeeding.

Do I need a flu test before taking Xofluza?

Not always. CDC tells clinicians not to wait for test results before starting treatment when flu is suspected, and says early treatment can be based on clinical judgment, including without an office visit. Your DrHouse doctor weighs your symptoms and how much flu is going around, and can refer you to a Labcorp location if a test would help.

What are the side effects of Xofluza?

Side effects were uncommon in clinical trials. In adults and teens, the most common were diarrhea (3%), bronchitis (3%), nausea (2%), sinusitis (2%) and headache (1%), and in children 5 to 11, vomiting and diarrhea (5% each). A serious allergic reaction is rare, but trouble breathing, swelling of the face or lips, or widespread hives after a dose means calling 911.

What should you avoid when taking Xofluza?

Don’t take Xofluza with dairy products, calcium-fortified drinks, antacids, some laxatives, or supplements containing calcium, iron, magnesium, selenium or zinc, because they bind to baloxavir and can make it work less well. If you plan to get the nasal spray flu vaccine, CDC advises waiting 17 days after a dose. Tell your doctor about every medicine and supplement you take.

Can you crush Xofluza?

The prescribing information doesn’t say whether Xofluza tablets can be crushed or split, so ask your pharmacist before changing how you take it. If swallowing a tablet is hard for you or your child, mention it during the visit. Your doctor may suggest a different antiviral, such as oseltamivir, which comes as a liquid as well as capsules.

Can I get Xofluza delivered?

In select areas, yes. If your doctor prescribes Xofluza, you can choose same-day delivery through our partner pharmacies, sometimes in as little as an hour.* You’ll need a photo ID at the door. You can also pick it up at a pharmacy near you instead, where prescriptions usually arrive within 15 to 45 minutes after your visit.

• Genentech, Inc. “XOFLUZA (baloxavir marboxil) tablets, for oral use; XOFLUZA (baloxavir marboxil) for oral suspension: full prescribing information.” https://www.gene.com/download/pdf/xofluza_prescribing.pdf.
• Centers for Disease Control and Prevention, Influenza (Flu). “Influenza Antiviral Drug Baloxavir Marboxil.” https://www.cdc.gov/flu/treatment/baloxavir-marboxil.html.
• Centers for Disease Control and Prevention, Influenza (Flu). “Influenza Antiviral Medications: Summary for Clinicians.” https://www.cdc.gov/flu/hcp/antivirals/summary-clinicians.html.
• Centers for Disease Control and Prevention, Influenza (Flu). “Recommendations for Obstetric Health Care Providers Related to Use of Antiviral Medications for the Treatment and Prevention of Influenza.” https://www.cdc.gov/flu/hcp/antivirals/treatment_obstetric.html.
• Centers for Disease Control and Prevention, Influenza (Flu). “Treatment of Flu.” https://www.cdc.gov/flu/treatment/index.html.
• Centers for Disease Control and Prevention, Influenza (Flu). “Signs and Symptoms of Flu.” https://www.cdc.gov/flu/signs-symptoms/index.html.
• U.S. Food and Drug Administration, FDA News Release. “FDA Approves First Single-Dose Generic Treatment for Influenza.” https://www.fda.gov/news-events/press-announcements/fda-approves-first-single-dose-generic-treatment-influenza.
• American Academy of Pediatrics, HealthyChildren.org. “AAP (Influenza) Flu Prevention & Treatment Recommendations for 2026-27.” https://www.healthychildren.org/English/news/Pages/aap-(influenza)-flu-prevention-recommendations-for-2026-27.aspx.