What Is Celecoxib?

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) physicians prescribe to treat mild to moderate pain and to relieve arthritis. The medication is in the same group of drugs as naproxen and ibuprofen, which have similar effects.

Celecoxib goes by the brand name Celebrex. It is also an ingredient in the combination drug, Consensi, which contains amlodipine, a blood pressure-lowering medication. 

How Does Celecoxib Work?

Celecobix blocks cyclooxygenase-2 (COX-2), an enzyme that converts arachidonic acid into prostaglandin, an inflammatory molecule. By preventing the action of this enzyme, celecoxib reduces inflammation, lowering pain in patients. 

Celecoxib begins to work within a few hours of the first dose. Blocking the action of COX-2 stops the production of new inflammatory signaling molecules, which can result in reduced pain and swelling on the same day. However, the full effects of the medication may not be evident until after one to two weeks of daily administration. 

What Is Celecoxib Used For?

Because of its powerful anti-inflammatory effects, physicians regularly prescribe Celecoxib for osteoarthritis and rheumatoid arthritis. The drug can treat inflammation, swelling, stiffness, and joint pain. However, it cannot cure arthritis because it does not address the underlying causes. 

Some physicians also prescribe oral celecoxib for migraines and menstrual cramps. However, it cannot prevent these conditions. 

You cannot get celecoxib in the U.S. without a prescription, but you can get similar painkillers, like naproxen and ibuprofen, over the counter. 

What Are the Side Effects of Celecoxib?

The common side effects of celecoxib are: 

• Stomach pain
• Diarrhea or constipation
• Headache
• Dizziness
• Flatulence
• Rash
• Irritation of the sinus, nose, or throat

Serious side effects of taking the drug may include:

• Cardiovascular problems
• Gastrointestinal bleeding or ulceration
• Kidney function impairment
• Severe allergic reactions

Note, that the list above is not exhaustive. Patients should discuss all of the possible side effects of celecoxib with their doctor before taking the medication. 

Long-term use of celecoxib can cause gastrointestinal bleeding in some people. Pale skin or bloody stools could indicate an unfavorable reaction to the drug. 

Bleeding can occur because of NSAIDs’ effects on platelets in the blood that cause clots. Preventing them from clotting increases the risk of bleeding in the stomach, intestines, and colon. 

If you experience any of these effects, consult with your doctor immediately. Most side effects will go away by themselves, but others may require a change in medication. If you have any signs of an allergic reaction such as difficulty breathing seek medical attention immediately.

How to Take Celecoxib?

Patients typically take celecoxib by mouth once or twice daily, following their doctor’s prescription. Tablets come in capsule or pill form and are swallowed whole with water. 

Medical professionals often recommend taking celecoxib with food if you are taking a high dose. Eating and taking pills at the same time can reduce the risk of gastrointestinal disturbances. 

You can take celecoxib with water in the morning or evening. If you need to take two tablets daily, doctors usually recommend separating these by 12 hours. The dosage you receive will depend on your medical condition and individual needs. 

Frequently Asked Questions About Celecoxib 

What to Avoid While Taking Celecoxib?

Things you should avoid while taking celecoxib include:

• Alcohol – The combination of alcohol and celecoxib can increase the risk of stomach ulcers, bleeding, or liver problems.
• Certain medications – Consult your healthcare provider for guidance on potential interactions if you are taking other medication.
• High doses – Do not exceed the recommended dose, as higher doses are associated with an increased risk of cardiovascular events.

This list above isn’t exhaustive. It’s important to speak with your doctor before taking Celecoxib to discuss any potential interactions and the correct dosage for your individual needs.

Also, avoid doing any heavy physical activity or activities that require a higher level of mental alertness or coordination before you know how the drug affects you.

Celecoxib is also generally not recommended for pregnant women. Speak to your doctor if you are pregnant and considering taking Celecoxib.

Is Celecoxib Safe?

Generally, Celecoxib is considered to be a safe and effective medication for treating pain and inflammation caused by arthritis when used as prescribed by a healthcare provider.

However, there are certain risks associated with taking the medication and the safety and efficacy of the medication will ultimately depend on a variety of factors including the individual patient’s health status, the presence of other medical conditions, other medications being taken, and the duration and dose of the treatment.

So be sure to talk to your doctor about all possible risks and side effects before taking Celecoxib. This will help ensure that you are making an informed decision about whether or not it is the right medication for you.

How Long Does It Take for Celecoxib to Work?

The exact time it takes for celecoxib to work can vary based on individual patient factors, the dose taken, and the condition being treated.

Generally, you may start to feel relief from pain and inflammation within a few hours after taking the medication. The full anti-inflammatory effects might not be apparent until after a few days to a couple of weeks of regular use.

What Is the Typical Dosage for Celecoxib?

The dosage of celecoxib varies depending on the medical condition being treated and individual patient factors like age, weight, and other health conditions.

For most forms of arthritis, the typical starting dose will be around 100 mg to 200 mg taken once or twice daily. For other conditions, the dosage can be as high as 400mg.

Make sure to follow the specific instructions from your doctor for taking celecoxib. Don’t take more or less than prescribed, as this could result in a dangerous reaction.

Can You Get Celecoxib Over-The-Counter (OTC)?

Celecoxib is not available over-the-counter in the United States and must be prescribed by a healthcare provider.

Can I Get Celecoxib Online?

Yes, you can get a Celecoxib prescription online through DrHouse. Our US-licensed physicians can assess your condition and provide you with a prescription for Celecoxib if deemed appropriate.

For more detailed information about celecoxib, you can refer to the following sources:

• Celebrex prescription label, Food and Drug Administration (FDA).
• Celecoxib, MedlinePlus.
• Celecoxib, U.S. National Library of Medicine.

The content on this page has been medically reviewed for accuracy and comprehensiveness by Amy Dougherty, FNP-BC, AGAC