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Amitriptyline (Generic Elavil, Endep)
Amitriptyline is a prescription medicine that is predominantly used to treat the symptoms of depression and works on the central nervous system which increases the levels of specific chemicals in the brain.
This medicine is known as a tricyclic antidepressant (TCA) which is an older type of antidepressant, and is not traditionally recommended as the first port of call to treat depression because of the dangers if an overdose occurs, and can also cause more unpleasant side effects in comparison to traditional antidepressants Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs).
What is Amitriptyline Prescribed For?
Amitriptyline is predominately used to treat the symptoms of depression and works by increasing the amount of the essential substances in the brain that is vital to maintaining a mental balance.
Amitriptyline is also used in a number of other ailments, including the prevention of migraine headaches, postherpetic neuralgia (the pains or aches that could occur for a number of months or years after a shingles infection), and can also be used in the treatment of eating disorders as it reduces the desire to binge eat.
How Does Amitriptyline Work?
Amitriptyline is thought to work by increasing the levels of serotonin in your brain. Serotonin is a neurotransmitter that carries messages between nerve cells in the brain and the body, which plays a key role in a number of body functions such as mood, digestion, bone health, and sleep.
It can also change the way your nerves receive pain signals, which can alleviate symptoms if being taken for conditions like migraines or postherpetic neuralgia.
What Are The Side Effects of Amitriptyline?
It’s recommended not to use amitriptyline if you have either had a heart attack recently or have used an MAO inhibitor antidepressant in the last 14 days or have had an SSRI antidepressant in the last 5 weeks. It’s also important to speak to your doctor if you’ve had any of the following:
- Liver disease
- Heart disease
- Glaucoma
- Diabetes
- Mental illness, psychosis, bipolar disorder, or schizophrenia
There are a number of potential side effects of amitriptyline, including the following:
- Allergic reactions, such as swelling of the face, throat, tongue, or lips, difficulty breathing, or hives
- Unusual behavior or thoughts
- Confusion or hallucinations
- Constipation
- Unusual bleeding or you are easy to bruise
- Feeling light-headed
- Pressure, especially in the chest or pressure that spreads to your shoulder or jaw
- Difficulty urinating
Some other common side effects of amitriptyline include:
- Breast swelling in (women or men)
- Decreased sex drive
- Constipation or diarrhea
- Pain in the mouth
- Nausea, upset stomach, or vomiting
Frequently Asked Questions About Amitriptyline
Can you get amitriptyline over-the-counter (OTC)?
No, you cannot get amitriptyline over-the-counter (OTC). Amitriptyline is a prescription medication that can only be obtained with a valid prescription from a licensed healthcare provider.
Can you get an amitriptyline prescription online?
Yes, you can get an online prescription for amitriptyline from DrHouse. Our licensed physicians can conduct virtual consultations and prescribe amitriptyline if deemed appropriate after reviewing your medical history and current condition.
How to use amitriptyline?
Amitriptyline comes in tablet form to be taken by mouth and is usually taken between one and four times every day. When prescribed amitriptyline you should follow the directions on the label carefully. It is recommended to take amitriptyline at around the same time every day.
A typical dosage for symptoms of depression can vary. An initial dose could be 75 mg per day in divided doses and increased up to a maximum of 150 mg a day. A maintenance dose may be prescribed at 40 mg to 100 mg per day.
It is recommended that the dose should be taken in the late afternoon or at bedtime because of the sedative effects, and may take up to 30 days to deliver the full therapeutic effect.
For more detailed information about amitriptyline, you can refer to the following sources:
- Amitriptyline, MedlinePlus.
- Amitriptyline, U.S. National Library of Medicine.
- Amitriptyline, Drugs.com
The content on this page has been medically reviewed for accuracy and comprehensiveness by Amy Dougherty, FNP-BC, AGAC
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