Get a Zoloft
Prescription Online

Get a new Zoloft prescription or refill your medication online.

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Available in 50 states. No insurance needed.

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How to get a Zoloft prescription online?

Download the DrHouse app. Set up your free account in a minute.


Start a visit with an online doctor. Wait time is less than 15 minutes.


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How much does a visit to get a Zoloft prescription cost?

Physician Visit
One-time visit with a physician for diagnosis, treatment, Rx, labs, referrals, and doctor’s notes.
Copay or $129 without insurance.
24/7 virtual visits
See the first available physician, or schedule a visit with a physician you like.
Live customer support
Chat with our customer support whenever necessary. They are here for you 24/7.
Get a real doctor’s note
Get a doctor’s excuse and/or clearance for your school or work if needed.
100% treatment guarantee
You can request a refund after your visit if we are unable to provide care.
Having a visit does not guarantee a medication will be ordered or refilled. It is clinicians’ professional decision. It is prohibited by law to prescribe or refill controlled substances via virtual visits. Your provider may recommend follow-up care, including additional services that may not be included in visit price.

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Zoloft (Sertraline)

Zoloft, or Sertraline, is a Selective Serotonin Reuptake Inhibitor (SSRI) or antidepressant used to treat a variety of mental health conditions including depression, obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), social anxiety disorder, and panic disorder.

It also treats anxiety by slowing down the reabsorption of serotonin. Sertraline is the generic form of the brand-name drug Zoloft. It works in the brain by raising serotonin levels, which affects mood.

A Zoloft prescription or medication is taken by mouth as directed by your doctor. It’s typically taken once daily in the morning or evening. Dosage is determined and based on your specific medical condition and response to treatment. If you miss a dose then take it as soon as you can but never take two doses at one time. There have been instances when taking Zoloft can lead to small weight gain.

What is Zoloft Prescribed For?

Zoloft has been approved for and is used to treat major depressive disorder (MDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder. It can also be used in adults, children, and teens aged 6-17 for obsessive-compulsive disorder (OCD).

It is an antidepressant that’s prescribed for and treats a variety of mental health disorders. A doctor might prescribe Zoloft if you describe symptoms of having a depressed mood, a loss of interest in activities, low energy, and feelings of hopelessness and worthlessness. Never stop taking it without input and following the directions given by your doctor.

How Does Zoloft Work?

Zoloft is part of a group of medicines called Selective Serotonin Reuptake Inhibitors (SSRIs). How they are thought to work is by preventing the reuptake of serotonin by nerves. What this does is lead to an increase in serotonin concentration in the nerve synapse, which is the space between two nerves.

It ends up leaving more of the chemical, serotonin, available. Serotonin is a neurotransmitter. This neurotransmitter helps regular memory, learning, and mood. Experts believe that Zoloft (sertraline) is effective because of its ability to rebalance chemicals, such as serotonin, in the brain. Compared to other antidepressants, its activity against other neurotransmitters is less potent.

What Are The Side Effects of Zoloft?

There are side effects to know about and be aware of before taking and while taking Zoloft. For starters, it may cause drowsiness. However, there’s less potential for drowsiness than many other antidepressants. In addition, you might experience headaches, nausea, diarrhea, weight loss, insomnia, and sexual dysfunction.

The most common side effects that come with taking Zoloft are loss of appetite, nausea, indigestion, diarrhea, loose stool, increased sweating, tremors, or sexual problems. You can always contact your doctor or online pharmacy if you have questions about your side effects. Some patients might also notice a small weight gain in some cases.

Frequently Asked Questions About Zoloft (Sertraline)

Can You Get Zoloft Over the Counter?

No. You can’t buy Zoloft over the counter. A prescription is always necessary for all antidepressant medications.

How to Take Zoloft?

You take Zoloft by mouth and only as directed by your doctor. Typically, you’ll be instructed to take it once daily in the morning or evening, whichever works best for you. You can take it with or without food.

What to Avoid While Taking Zoloft?

Other drugs may interact with sertraline, so always tell your doctor about all other medicines that you’re taking before obtaining a Zoloft online prescription.

Also, too much serotonin can cause serotonin syndrome. Therefore, those taking sertraline need to avoid nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen, aspirin, ibuprofen; blood thinners; as well as MAOIs or other medications that increase serotonin levels.

It’s also advised that you avoid drinking alcohol or using illegal drugs while you are taking any kind of antidepressant medication.

How Long Does Zoloft Take to Work?

If you continue with regular dosing then it can take roughly four to six weeks for Zoloft to reach its full therapeutic effect and help relieve the symptoms that come with depression. While some patients may require a longer period, some notice the effects of it working in the first one to two weeks. Keep in mind that it doesn’t work immediately.


For more detailed information about Zoloft (Sertraline), you can refer to the following sources:


The content on this page has been medically reviewed for accuracy and comprehensiveness by Amy Dougherty, FNP-BC, AGAC 

Content on the DrHouse website is written by our medical content team and reviewed by qualified MDs, PhDs, NPs, and PharmDs. We follow strict content creation guidelines to ensure accurate medical information. However, this content is for informational purposes only and not a substitute for professional medical advice, diagnosis, or treatment. For more information read our medical disclaimer.

Always consult with your physician or other qualified health providers about medical concerns. Never disregard professional medical advice or delay seeking it based on what you read on this website.

If you are experiencing high fever (>103F/39.4C), shortness of breath, difficulty breathing, chest pain, heart palpitations, abnormal bruising, abnormal bleeding, extreme fatigue, dizziness, new weakness or paralysis, difficulty with speech, confusion, extreme pain in any body part, or inability to remain hydrated or keep down fluids or feel you may have any other life-threatening condition, please go to the emergency department or call 911 immediately.

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Frequently asked questions

  • Yes, you can get a new prescription or refill an existing one online through DrHouse. You just need to start a consultation with one of our licensed providers and they will be able to assess your needs and provide you with a prescription if necessary.

    Please note that the final decision always rests with the doctor based on their professional judgment and your health needs.

  • There are certain medications that cannot be prescribed online by DrHouse physicians due to safety reasons. These include controlled substances, such as opioids and other narcotics, as well as drugs with a high potential for abuse or dependence. DrHouse physicians also don’t prescribe Gabapentin, medical marijuana, muscle relaxants, and HRT medications.

  • With DrHouse getting a new prescription or a refill for your current Rx is a straightforward and quick process. All you need to do is follow a few easy steps:

    • Download the DrHouse telehealth app on your mobile device.
    • Create an account by providing basic information and medical history.
    • Start an on-demand virtual video consultation with one of our licensed physicians.
    • Discuss your medical needs and concerns with one of our physicians.
    • A doctor will review your medical history, symptoms, and current medications (if any) to determine if an online prescription is appropriate for you.
    • If a physician approves, they will electronically send a new prescription or refill request to the pharmacy of your choice.
    • Pick up your medication from the pharmacy.

    DrHouse makes it easy for you to get an online prescription from the comfort of your own home. No more waiting in line at the doctor’s office or pharmacy, and no need to take time off work to see a doctor. Our telehealth platform allows you to access quality medical care from anywhere with an internet connection.

    For more information about how our telehealth platform works visit our “How DrHouse Works” page.

  • During your virtual consultation with a DrHouse physician, you will have the opportunity to discuss your medical needs and concerns.

    The consultation will consist of a video call where a physician will assess your medical history and ask you questions about your symptoms and any other relevant information. This is to ensure that a physician has all the necessary information to make an informed decision about your prescription.

    You can also ask any questions or clarify any doubts you may have about your condition or medication. Our physicians are happy to address any concerns you may have.

    Once a physician has assessed your needs, they will determine if and what type of prescription is appropriate for you. If a new prescription or refill is approved, a doctor will send it electronically to your chosen pharmacy.

  • With our on-demand telehealth service, you have the opportunity to see the first available doctor in as little as 10 to 15 minutes. However, the exact consult time will depend on the complexity of your case and the thoroughness required by the healthcare provider to make an informed decision.

  • Absolutely, it is safe to get an online prescription from DrHouse. We are committed to ensuring the highest standards of patient safety and privacy.

    All our providers are highly qualified US-based physicians and often affiliated with major hospitals. They are board-certified and from the top U.S. medical schools with an average of 20 years of experience.

    We strictly adhere to HIPAA regulations, ensuring your personal and medical information is kept secure and confidential. Also, we comply with all applicable state and federal laws related to telehealth and the prescribing of medications.

    Therefore, you can rest assured knowing that your safety and privacy are our top priorities when you use DrHouse’s services.

  • DrHouse strives to provide accessible and affordable telehealth services. DrHouse urgent care, primary care, and specialist visits are $129 or your copay. This includes everything from your initial consultation through to the prescription of your medication.

    The cost of a doctor’s visit may be covered fully by your insurance. A typical copay is around $25. We recommend checking with your insurance provider to understand the extent of your coverage for telehealth services.

    To learn more about how much DrHouse costs, visit our pricing page

  • Yes, DrHouse accepts most major insurances, including Blue Cross Blue Shield, Aetna, and Medicare. The extent of coverage may vary depending on your individual plan.

  • Our physicians are able to prescribe up to a 90-day prescription without labs for any previously prescribed medication if it’s medically appropriate and is not classified as a controlled substance.

    DrHouse physicians also don’t prescribe Gabapentin, medical marijuana, muscle relaxants, and HRT medications.

    DrHouse physicians use their medical judgment to determine whether to prescribe and the duration.

    In certain cases, the prescription may be limited to 30 days or less. There also may be a 12-month cap for some prescriptions without labs. For medications requiring annual monitoring (such as blood work or imaging), the maximum prescription limit is 90 days within a year without labs.

    DrHouse physicians can refer patients to labs for longer prescription periods or refills.